ASSR is an open access journal, aims at rapid publication of concise research papers of a broad interest in Physical education fields. Subject areas include all the current fields of interest represented by the Committees of the Design Scientific Renaissance. ASSR welcomes papers and articles in sport and physical education, fields of ASSR includes but not limited to: sport for all; Exercise physiology; Moths of training and coaching;Sport’s performance and analysis
JACSTR is an open access journal, aims at rapid publication of concise research papers of a broad interest in computer science and information technology fields.
JALOR aims at rapid publication of concise research papers of a broad interest in laser and optics fields. Subject areas include all the current fields of interest represented by the Committees of the Design Scientific Renaissance. JALOR accepts papers and articles in fields, including but not limited to the following: Actuator; Detectors; Ferroelectric And Ferromagnetic Materials; Filters; Holography; Laser Accessories And Optics
Journal of Advanced Medical Research (JAMR) is an open access journal, provides rapid publication of various articles in the fields of Medical, Dentistry, Pharmacy, Comparative Veterinary and Medical sciences, and related disciplines. JAMR seeks to publish experimental and theoretical research results of outstanding significance in the form of original articles, reviews, case reports, short reports, or letters to the editor.
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JMMR aims at rapid publication of concise research papers of a broad interest in marketing fields. JMMR welcomes papers and articles in marketing fields, including but not limited to the following: Consumer behavior; CRM; Customer Knowledge Management; Advertising economies; Consumer modeling; Marketing research; Interactive marke
The Journal of Purity, Utility Reaction & ENVIRONMENT focuses upon six aspects of chemical engineering: chemical reaction engineering, environment chemical engineering, and materials synthesis and processing, catalyst surface reaction, optimization and control.
Cancer Drug Discovery Suggestions
by Branden Everett (2020-09-15)
There are already regular breakthroughs in our understanding of cancer, but little progress in its treatment. Modern research into cancer began in the 1940's and 50's when scientists isolated substances that killed cancer cells growing in a petri dish, or leukaemia cells in laboratory mice. Early successes in chemotherapy set the pace and received much media exposure, despite the fact that they only applied to 5% of cancer treatments at most.
Serving humanity by solving its major diseases has a celebrity status, there's a lot of kudos and an air of Hollywood linked to such things. Cancer research is high profile activity and every now and then a scientific treatment is discovered that gains wide recognition, such as the HPV-16 trial, but it only applies itself to the management of a small percentage of cancers. Mass-media hype is involved in the problem of how we see cancer. Early discoveries set up an expectation that there was a cure-all treatment, a 'magic bullet' that might make its discoverer famous by curing cancer throughout the world. The idea stems in part from aspirin, the original bullet that magically finds its way to the anguish and diminishes it.
In the 1950's and 60's huge and expensive research projects were set up to test every known substance to view if it effected cancer cells. You might remember the discovery of the Madagascar Periwinkle (Catharansus Roseus), which revealed alkaloids (vinblastine and vincristine) that are still used in chemotherapy today. Taxol, a treatment for ovarian and breast cancer originally came from the Pacific Yew tree. A treatment for testicular cancer and small-cell lung cancer drug treatments called 'Etoposide' was derived from the May apple. In 'Plants Used Against Cancer' by Jonathan Hartwell over three thousand plants are identified from medical and folklore sources for the treatment of cancer, about half of that have been shown to have some impact on cancer cells in a test tube.
When these plants are made into synthetic drugs, single chemicals are isolated and the rest of the plant is usually thrown away. The medicinally active molecules are extracted from the plant and modified until they are chemically unique. Then the compound is patented, given a brand name and tested.
In the first phase it will generally be tested on animals, the next phase will decide dosage levels and in phase 3 it is tested on people. Through the time it really is approved through the Federal Drugs Authority (in U.S.A.) or the Medicines and Healthcare Products Regulation Agency (M.H.R.A.) in Britain, the development costs for a whole new drug can reach five hundred million dollars, which eventually has to be recouped from the consumer.